Aspartate is an endogenous metabolic limitation for tumour growth

Aspartate is an endogenous metabolic limitation for tumour growth

Defining the metabolic limitations of tumour growth will help to develop cancer therapies 1 . Cancer cells proliferate slower in tumours than in standard culture conditions, indicating that a metabolic limitation may restrict cell proliferation in vivo. Aspartate synthesis can limit cancer cell prol...

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Bibliographic Details
Main Authors: Sullivan, Lucas B. (Author), Luengo, Alba (Author), Danai, Laura V. (Author), Bush, Lauren N. (Author), Diehl, Frances F. (Author), Hosios, Aaron M. (Author), Lau, Allison N. (Author), Elmiligy, Sarah (Author), Lewis, Caroline A. (Author), Vander Heiden, Matthew G. (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-04-30T13:00:27Z.
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