Induction and transcriptional regulation of the co-inhibitory gene module in T cells
The expression of co-inhibitory receptors, such as CTLA-4 and PD-1, on effector T cells is a key mechanism for ensuring immune homeostasis. Dysregulated expression of co-inhibitory receptors on CD4+ T cells promotes autoimmunity, whereas sustained overexpression on CD8+ T cells promotes T cell dysfu...
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Springer Nature,
2020-05-06T15:28:44Z.
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| Subjects: | |
| Online Access: | Get fulltext |