CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

CRISPR-mediated modeling and functional validation of candidate tumor suppressor genes in small cell lung cancer

Small cell lung cancer (SCLC) is a highly aggressive subtype of lung cancer that remains among the most lethal of solid tumor malignancies. Recent genomic sequencing studies have identified many recurrently mutated genes in human SCLC tumors. However, the functional roles of most of these genes rema...

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Main Authors: Ng, Sheng Rong (Author), Rideout, William M. (Author), Akama-Garren, Elliot H. (Author), Bhutkar, Arjun (Author), Mercer, Kim L. (Author), Schenkel, Jason M. (Author), Bronson, Roderick T. (Author), Jacks, Tyler E (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Harvard University- (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Proceedings of the National Academy of Sciences, 2020-05-11T16:58:45Z.
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