Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma

IDH1 mutations are common in low-grade gliomas and secondary glioblastomas and cause overproduction of (R)-2HG. (R)-2HG modulates the activity of many enzymes, including some that are linked to transformation and some that are probably bystanders. Although prior work on (R)-2HG targets focused on 2O...

Full description

Bibliographic Details
Main Authors: McBrayer, Samuel K. (Author), Mayers, Jared R. (Author), DiNatale, Gabriel J. (Author), Shi, Diana D. (Author), Khanal, Januka (Author), Chakraborty, Abhishek A. (Author), Sarosiek, Kristopher A. (Author), Briggs, Kimberly J. (Author), Robbins, Alissa K. (Author), Sewastianik, Tomasz (Author), Shareef, Sarah J. (Author), Olenchock, Benjamin A. (Author), Parker, Seth J. (Author), Tateishi, Kensuke (Author), Spinelli, Jessica B. (Author), Islam, Mirazul (Author), Haigis, Marcia C. (Author), Looper, Ryan E. (Author), Ligon, Keith L. (Author), Bernstein, Bradley E. (Author), Carrasco, Ruben D. (Author), Cahill, Daniel P. (Author), Asara, John M. (Author), Metallo, Christian M. (Author), Yennawar, Neela H. (Author), Vander Heiden, Matthew G. (Author), Kaelin, William G. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-05-11T18:37:39Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items