Implications of human genetic variation in CRISPR-based therapeutic genome editing
CRISPR-Cas genome-editing methods hold immense potential as therapeutic tools to fix disease-causing mutations at the level of DNA. In contrast to typical drug development strategies aimed at targets that are highly conserved among individual patients, treatment at the genomic level must contend wit...
Main Authors: | Scott, David A (Author), Zhang, Feng (Author) |
---|---|
Other Authors: | Broad Institute of MIT and Harvard (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer Nature,
2020-05-11T18:38:40Z.
|
Subjects: | |
Online Access: | Get fulltext |
Similar Items
-
Characterizing human regulatory genetic variation using CRISPR/Cas9 genome editing
by: Brandt, Margot
Published: (2020) -
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors
by: Wang, Dan, et al.
Published: (2022) -
CRISPR-Based Therapeutic Genome Editing: Strategies and In Vivo Delivery by AAV Vectors
by: Wang, D, et al.
Published: (2021) -
CRISPR-mediated genome editing and human diseases
by: Liquan Cai, et al.
Published: (2016-12-01) -
Engineering of CRISPR-Cas12b for human genome editing
by: Jonathan Strecker, et al.
Published: (2019-01-01)