Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity

Acute myeloid leukemia (AML) is a heterogeneous disease that resides within a complex microenvironment, complicating efforts to understand how different cell types contribute to disease progression. We combined single-cell RNA sequencing and genotyping to profile 38,410 cells from 40 bone marrow asp...

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Main Authors: van Galen, Peter (Author), Hovestadt, Volker (Author), Wadsworth II, Marc H. (Author), Hughes, Travis K. (Author), Griffin, Gabriel K. (Author), Battaglia, Sofia (Author), Verga, Julia A. (Author), Stephansky, Jason (Author), Pastika, Timothy J. (Author), Lombardi Story, Jennifer (Author), Pinkus, Geraldine S. (Author), Pozdnyakova, Olga (Author), Galinsky, Ilene (Author), Stone, Richard M. (Author), Graubert, Timothy A. (Author), Shalek, Alex K. (Author), Aster, Jon C. (Author), Lane, Andrew A. (Author), Bernstein, Bradley E. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-05-11T19:28:19Z.
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