Quantification of somatic mutation flow across individual cell division events by lineage sequencing

Mutation data reveal the dynamic equilibrium between DNA damage and repair processes in cells and are indispensable to the understanding of age-related diseases, tumor evolution, and the acquisition of drug resistance. However, available genome-wide methods have a limited ability to resolve rare som...

Full description

Bibliographic Details
Main Authors: Kimmerling, Robert John (Author), Elacqua, Joshua J. (Author), Blainey, Paul C (Author), Manalis, Scott R (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Cold Spring Harbor Laboratory, 2020-05-14T13:52:28Z.
Subjects:
Online Access:Get fulltext