Diversity and evolution of class 2 CRISPR-Cas systems

Diversity and evolution of class 2 CRISPR-Cas systems

Class 2 CRISPR-Cas systems are characterized by effector modules that consist of a single multidomain protein, such as Cas9 or Cpf1. We designed a computational pipeline for the discovery of novel class 2 variants and used it to identify six new CRISPR-Cas subtypes. The diverse properties of these n...

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Main Authors: Shmakov, Sergey (Author), Smargon, Aaron Andrew (Author), Scott, David (David Arthur) (Author), Cox, David D. (Author), Pyzocha, Neena (Author), Yan, Winston Xia (Author), Abudayyeh, Omar O. (Author), Gootenberg, Jonathan S (Author), Makarova, Kira S. (Author), Wolf, Yuri I. (Author), Severinov, Konstantin (Author), Zhang, Feng (Author), Koonin, Eugene V. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Harvard University- (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-20T19:02:48Z.
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