Inhibition of tyrosine-phosphorylated STAT3 in human breast and lung cancer cells by Manuka honey is mediated by selective antagonism of the IL-6 receptor

Inhibition of tyrosine-phosphorylated STAT3 in human breast and lung cancer cells by Manuka honey is mediated by selective antagonism of the IL-6 receptor

Aberrantly high levels of tyrosine-phosphorylated signal transducer and activator of transcription 3 (p-STAT3) are found constitutively in ~50% of human lung and breast cancers, acting as an oncogenic transcription factor. We previously demonstrated that Manuka honey (MH) inhibits p-STAT3 in breast...

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Main Authors: Aryappalli, Priyanka (Author), Shabbiri, Khadija (Author), Masad, Razan J. (Author), Al-Marri, Roadha H. (Author), Haneefa, Shoja M. (Author), Mohamed, Yassir A. (Author), Arafat, Kholoud (Author), Attoub, Samir (Author), Cabral-Marques, Otavio (Author), Ramadi, Khalil (Author), Fernandez-Cabezudo, Maria J. (Author), al-Ramadi, Basel K. (Author)
Other Authors: Harvard University- (Contributor)
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute, 2020-05-21T19:16:51Z.
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