Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations
A key public health need is to identify individuals at high risk for a given disease to enable enhanced screening or preventive therapies. Because most common diseases have a genetic component, one important approach is to stratify individuals based on inherited DNA variation 1 . Proposed clinical a...
Main Authors: | Khera, Amit V. (Author), Chaffin, Mark (Author), Aragam, Krishna G. (Author), Haas, Mary E. (Author), Roselli, Carolina (Author), Choi, Seung Hoan (Author), Natarajan, Pradeep (Author), Lander, Eric Steven (Author), Lubitz, Steven A. (Author), Ellinor, Patrick T. (Author), Kathiresan, Sekar (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Broad Institute of MIT and Harvard (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC,
2020-05-21T19:54:56Z.
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Subjects: | |
Online Access: | Get fulltext |
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