Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

Shank3 mutation in a mouse model of autism leads to changes in the S-nitroso-proteome and affects key proteins involved in vesicle release and synaptic function

Mutation in the SHANK3 human gene leads to different neuropsychiatric diseases including Autism Spectrum Disorder (ASD), intellectual disabilities and Phelan-McDermid syndrome. Shank3 disruption in mice leads to dysfunction of synaptic transmission, behavior, and development. Protein S-nitrosylation...

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Bibliographic Details
Main Authors: Amal, Haitham (Author), Barak, Boaz (Author), Bhat, Vadiraja (Author), Gong, Guanyu (Author), Joughin, Brian Alan (Author), Wang, Xin (Author), Wishnok, John S. (Author), Feng, Guoping (Author), Tannenbaum, Steven R (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-21T20:49:26Z.
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