Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Discovery and optimization of piperazine-1-thiourea-based human phosphoglycerate dehydrogenase inhibitors

Proliferating cells, including cancer cells, obtain serine both exogenously and via the metabolism of glucose. By catalyzing the first, rate-limiting step in the synthesis of serine from glucose, phosphoglycerate dehydrogenase (PHGDH) controls flux through the biosynthetic pathway for this important...

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Main Authors: Rohde, Jason M. (Author), Brimacombe, Kyle R. (Author), Liu, Li (Author), Pacold, Michael Edward (Author), Yasgar, Adam (Author), Cheff, Dorian M. (Author), Lee, Tobie D. (Author), Rai, Ganesha (Author), Baljinnyam, Bolormaa (Author), Li, Zhuyin (Author), Simeonov, Anton (Author), Hall, Matthew D. (Author), Shen, Min (Author), Sabatini, David (Author), Boxer, Matthew B. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-05-22T19:23:24Z.
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