Comprehensive substrate specificity profiling of the human Nek kinome reveals unexpected signaling outputs
© van de Kooij et al. Human NimA-related kinases (Neks) have multiple mitotic and non-mitotic functions, but few substrates are known. We systematically determined the phosphorylation-site motifs for the entire Nek kinase family, except for Nek11. While all Nek kinases strongly select for hydrophobi...
Main Authors: | Van de Kooij, Bert (Author), Creixell Morera, Pau (Author), Van Vlimmeren, Anne Elise (Author), Joughin, Brian Alan (Author), Yaffe, Michael B (Author) |
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Other Authors: | Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor) |
Format: | Article |
Language: | English |
Published: |
eLife Sciences Publications, Ltd,
2020-05-27T17:03:25Z.
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Subjects: | |
Online Access: | Get fulltext |
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