Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

Mitogenic and progenitor gene programmes in single pilocytic astrocytoma cells

Pilocytic astrocytoma (PA), the most common childhood brain tumor, is a low-grade glioma with a single driver BRAF rearrangement. Here, we perform scRNAseq in six PAs using methods that enabled detection of the rearrangement. When compared to higher-grade gliomas, a strikingly higher proportion of t...

Full description

Bibliographic Details
Main Authors: Reitman, Zachary J. (Author), Paolella, Brenton R. (Author), Bergthold, Guillaume (Author), Pelton, Kristine (Author), Becker, Sarah (Author), Jones, Robert (Author), Sinai, Claire E. (Author), Malkin, Hayley (Author), Huang, Ying (Author), Grimmet, Leslie (Author), Herbert, Zachary T. (Author), Sun, Yu (Author), Weatherbee, Jessica L. (Author), Alberta, John A. (Author), Daley, John F. (Author), Rozenblatt-Rosen, Orit (Author), Condurat, Alexandra L. (Author), Qian, Kenin (Author), Khadka, Prasidda (Author), Segal, Rosalind A. (Author), Haas-Kogan, Daphne (Author), Filbin, Mariella G. (Author), Suva, Mario L. (Author), Regev, Aviv (Author), Stiles, Charles D. (Author), Kieran, Mark W. (Author), Goumnerova, Liliana (Author), Ligon, Keith L. (Author), Shalek, Alexander K (Author), Bandopadhayay, Pratiti (Author), Beroukhim, Rameen (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Massachusetts Institute of Technology. Department of Chemistry (Contributor), Broad Institute of MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-05-27T19:16:59Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items