Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

Enhanced ER proteostasis and temperature differentially impact the mutational tolerance of influenza hemagglutinin

We systematically and quantitatively evaluate whether endoplasmic reticulum (ER) proteostasis factors impact the mutational tolerance of secretory pathway proteins. We focus on influenza hemaggluttinin (HA), a viral membrane protein that folds in the host's ER via a complex pathway. By integrat...

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Bibliographic Details
Main Authors: Phillips, Angela Marie (Author), Gonzalez, Luna O. (Author), Butty, Vincent L G (Author), Shoulders, Matthew D. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Mathematics (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: eLife Sciences Publications, Ltd, 2020-05-28T16:28:36Z.
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