Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

Loss of Elongator- and KEOPS-Dependent tRNA Modifications Leads to Severe Growth Phenotypes and Protein Aggregation in Yeast

Modifications found in the Anticodon Stem Loop (ASL) of tRNAs play important roles in regulating translational speed and accuracy. Threonylcarbamoyl adenosine (t6A37) and 5-methoxycarbonyl methyl-2-thiouridine (mcm5s2U34) are critical ASL modifications that have been linked to several human diseases...

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Main Authors: Pollo-Oliveira, Leticia (Author), Klassen, Roland (Author), Davis, Nick (Author), Ciftci, Akif (Author), Bacusmo, Jo Marie (Author), Martinelli, Maria (Author), DeMott, Michael S. (Author), Begley, Thomas J. (Author), Dedon, Peter C (Author), Schaffrath, Raffael (Author), de Crécy-Lagard, Valérie (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Multidisciplinary Digital Publishing Institute, 2020-05-29T14:59:03Z.
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