A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production

A High-Throughput Assay for Collagen Secretion Suggests an Unanticipated Role for Hsp90 in Collagen Production

Collagen overproduction is a feature of fibrosis and cancer, while insufficient deposition of functional collagen molecules and/or the secretion of malformed collagen is common in genetic disorders like osteogenesis imperfecta. Collagen secretion is an appealing therapeutic target in these and other...

Full description

Bibliographic Details
Main Authors: Wong, Madeline Y. (Author), Doan, Ngoc Duc (Author), DiChiara, Andrew Stephen (Author), Papa, Louis John (Author), Cheah, Jaime H (Author), Soule, Christian K. (Author), Watson, Nicki E. (Author), Shoulders, Matthew D. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Whitehead Institute for Biomedical Research (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2020-06-02T16:47:48Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items