Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

Integrative molecular and clinical modeling of clinical outcomes to PD1 blockade in patients with metastatic melanoma

Immune-checkpoint blockade (ICB) has demonstrated efficacy in many tumor types, but predictors of responsiveness to anti-PD1 ICB are incompletely characterized. In this study, we analyzed a clinically annotated cohort of patients with melanoma (n = 144) treated with anti-PD1 ICB, with whole-exome an...

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Main Authors: Liu, David V. (Author), Liu, Derek (Author), Jerby-Arnon, Livnat (Author), Vokes, Natalie I. (Author), Margolis, Claire A. (Author), Conway, Jake (Author), He, Meng Xiao (Author), Elmarakeby, Haitham (Author), Dietlein, Felix (Author), Miao, Diana (Author), Tracy, Adam (Author), Izar, Benjamin (Author), Regev, Aviv (Author), Van Allen, Eliezer M. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-06-17T18:36:59Z.
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