Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Slow Delivery Immunization Enhances HIV Neutralizing Antibody and Germinal Center Responses via Modulation of Immunodominance

Conventional immunization strategies will likely be insufficient for the development of a broadly neutralizing antibody (bnAb) vaccine for HIV or other difficult pathogens because of the immunological hurdles posed, including B cell immunodominance and germinal center (GC) quantity and quality. We f...

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Main Authors: Cirelli, Kimberly M. (Author), Carnathan, Diane G. (Author), Nogal, Bartek (Author), Martin, Jacob T. (Author), Rodriguez, Oscar L. (Author), Upadhyay, Amit A. (Author), Enemuo, Chiamaka A. (Author), Gebru, Etse H. (Author), Choe, Yury (Author), Viviano, Federico (Author), Nakao, Catherine (Author), Pauthner, Matthias G. (Author), Reiss, Samantha (Author), Cottrell, Christopher A. (Author), Smith, Melissa L. (Author), Bastidas, Raiza (Author), Gibson, William (Author), Wolabaugh, Amber N. (Author), Melo, Mariane Bandeira (Author), Cossette, Benjamin (Author), Kumar, Venkatesh (Author), Patel, Nirav B. (Author), Tokatlian, Talar (Author), Menis, Sergey (Author), Kulp, Daniel W. (Author), Burton, Dennis R. (Author), Murrell, Ben (Author), Schief, William R. (Author), Bosinger, Steven E. (Author), Ward, Andrew B. (Author), Watson, Corey T. (Author), Silvestri, Guido (Author), Irvine, Darrell J (Author), Crotty, Shane (Author)
Other Authors: Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-06-22T20:38:39Z.
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