Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

Microtubule-Based Control of Motor-Clutch System Mechanics in Glioma Cell Migration

Microtubule-targeting agents (MTAs) are widely used chemotherapy drugs capable of disrupting microtubule-dependent cellular functions, such as division and migration. We show that two clinically approved MTAs, paclitaxel and vinblastine, each suppress stiffness-sensitive migration and polarization c...

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Bibliographic Details
Main Authors: Prahl, Louis S. (Author), Bangasser, Patrick F. (Author), Stopfer, Lauren Elizabeth (Author), Hemmat, Mahya (Author), White, Forest M. (Author), Rosenfeld, Steven S. (Author), Odde, David J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Cell Press, 2020-06-23T18:45:48Z.
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