Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer

Targeting MUC1-C suppresses BCL2A1 in triple-negative breast cancer

B-cell lymphoma 2-related protein A1 (BCL2A1) is a member of the BCL-2 family of anti-apoptotic proteins that confers resistance to treatment with anti-cancer drugs; however, there are presently no agents that target BCL2A1. The MUC1-C oncoprotein is aberrantly expressed in triple-negative breast ca...

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Main Authors: Hiraki, Masayuki (Author), Maeda, Takahiro (Author), Mehrotra, Neha (Author), Jin, Caining (Author), Alam, Maroof (Author), Bouillez, Audrey (Author), Hata, Tsuyoshi (Author), Tagde, Ashujit (Author), Keating, Amy E. (Author), Kharbanda, Surender (Author), Singh, Harpal (Author), Kufe, Donald (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-06-23T21:35:05Z.
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