Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

Antigen-specific antibody Fc glycosylation enhances humoral immunity via the recruitment of complement

HIV-specific broadly neutralizing antibodies (bNAbs) confer protection after passive immunization, but the immunological mechanisms that drive their development are poorly understood. Structural features of bNAbs indicate that they originate from extensive germinal center (GC) selection, which relie...

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Main Authors: Lofano, Giuseppe (Author), Gorman, Matthew J. (Author), Yousif, Ashraf S. (Author), Yu, Wen-Han (Author), Fox, Julie M. (Author), Dugast, Anne-Sophie (Author), Ackerman, Margaret E. (Author), Suscovich, Todd J. (Author), Weiner, Joshua (Author), Barouch, Dan (Author), Streeck, Hendrik (Author), Little, Susan (Author), Smith, Davey (Author), Richman, Douglas (Author), Lauffenburger, Douglas A (Author), Walker, Bruce (Author), Diamond, Michael S. (Author), Alter, Galit (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2020-06-23T21:48:39Z.
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