Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence

Cell size varies greatly between cell types, yet within a specific cell type and growth condition, cell size is narrowly distributed. Why maintenance of a cell-type specific cell size is important remains poorly understood. Here we show that growing budding yeast and primary mammalian cells beyond a...

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Main Authors: Neurohr, Gabriel (Author), Terry, Rachel L. (Author), Lengefeld, Jette (Author), Bonney, Megan Ellis (Author), Brittingham, Gregory P. (Author), Moretto, Fabien (Author), Miettinen, Teemu P (Author), Vaites, Laura Pontano (Author), Soares, Luis M. (Author), Paulo, Joao A. (Author), Harper, J. Wade (Author), Buratowski, Stephen (Author), Manalis, Scott R (Author), van Werven, Folkert J. (Author), Holt, Liam J. (Author), Amon, Angelika B (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-06-24T14:46:50Z.
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