Protein aggregation mediates stoichiometry of protein complexes in aneuploid cells
Aneuploidy, a condition characterized by chromosome gains and losses, causes reduced fitness and numerous cellular stresses, including increased protein aggregation. Here, we identify protein complex stoichiometry imbalances as a major cause of protein aggregation in aneuploid cells. Subunits of pro...
Main Authors: | , , , , , , , , |
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Other Authors: | |
Format: | Article |
Language: | English |
Published: |
Cold Spring Harbor Laboratory,
2020-06-25T19:24:27Z.
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Subjects: | |
Online Access: | Get fulltext |