The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs

The helicase Ded1p controls use of near-cognate translation initiation codons in 5' UTRs

The conserved and essential DEAD-box RNA helicase Ded1p from yeast and its mammalian orthologue DDX3 are critical for the initiation of translation 1 . Mutations in DDX3 are linked to tumorigenesis 2-4 and intellectual disability 5, and the enzyme is targeted by a range of viruses 6 . How Ded1p and...

Full description

Bibliographic Details
Main Authors: Guenther, Ulf-Peter (Author), Weinberg, David E. (Author), Zubradt, Meghan M. (Author), Tedeschi, Frank A. (Author), Stawicki, Brittany N. (Author), Zagore, Leah L. (Author), Brar, Gloria A. (Author), Licatalosi, Donny D. (Author), Bartel, David (Author), Weissman, Jonathan S. (Author), Jankowsky, Eckhard (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-06-26T14:52:38Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items