m⁶A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis

m⁶A modification of a 3' UTR site reduces RME1 mRNA levels to promote meiosis

Despite the vast number of modification sites mapped within mRNAs, known examples of consequential mRNA modifications remain rare. Here, we provide multiple lines of evidence to show that Ime4p, an N6-methyladenosine (m6A) methyltransferase required for meiosis in yeast, acts by methylating a site i...

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Bibliographic Details
Main Authors: Bushkin, G. Guy (Author), Morgan, Jeffrey T. (Jeffrey Thomas) (Author), Richardson, Kris (Author), Lewis, Caroline (Author), Chan, Sze Ham (Author), Bartel, David (Author), Fink, Gerald R (Author)
Other Authors: Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-07-07T17:28:10Z.
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