Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis

Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs), promoting inflammation and coagulation. Patients...

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Bibliographic Details
Main Authors: Frydman, Galit H. (Author), Tessier, Shannon N. (Author), Wong, Keith H. K. (Author), Vanderburg, Charles R. (Author), Fox, James G (Author), Toner, Mehmet (Author), Tompkins, Ronald G. (Author), Irimia, Daniel (Author)
Other Authors: Massachusetts Institute of Technology. Division of Comparative Medicine (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-07-10T20:55:13Z.
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