Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis
Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs), promoting inflammation and coagulation. Patients...
| Main Authors: | , , , , , , , |
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| Other Authors: | , |
| Format: | Article |
| Language: | English |
| Published: |
Springer Science and Business Media LLC,
2020-07-10T20:55:13Z.
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| Subjects: | |
| Online Access: | Get fulltext |