Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems

Pro-organic radical contrast agents ("pro-ORCAs") for real-time MRI of pro-drug activation in biological systems

Nitroxide-based organic-radical contrast agents (ORCAs) are promising as safe next-generation magnetic resonance imaging (MRI) tools. Nevertheless, stimuli-responsive ORCAs that enable MRI monitoring of prodrug activation have not been reported; such systems could open new avenues for prodrug valida...

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Main Authors: Nguyen, Hung VanThanh (Author), Detappe, Alexandre (Author), Harvey, Peter (Author), Gallagher, Nolan (Author), Mathieu, Clelia (Author), Agius, Michael P. (Author), Zavidij, Oksana (Author), Wang, Wencong (Author), Jiang, Yivan (Author), Rajca, Andrzej (Author), Jasanoff, Alan Pradip (Author), Ghobrial, Irene M. (Author), Ghoroghchian, Paiman Peter (Author), Johnson, Jeremiah A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Nuclear Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Royal Society of Chemistry (RSC), 2020-07-14T20:57:47Z.
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