Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

Innate immune recognition of glycans targets HIV nanoparticle immunogens to germinal centers

In vaccine design, antigens are often arrayed in a multivalent nanoparticle form, but in vivo mechanisms underlying the enhanced immunity elicited by such vaccines remain poorly understood. We compared the fates of two different heavily glycosylated HIV antigens, a gp120-derived mini-protein and a l...

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Bibliographic Details
Main Authors: Tokatlian, Talar (Author), Read, Benjamin J. (Author), Jones, Christopher A. (Author), Kulp, Daniel W. (Author), Menis, Sergey (Author), Chang, Jason Y. H. (Author), Steichen, Jon M. (Author), Kumari, Sudha (Author), Allen, Joel D. (Author), Dane, Eric L. (Author), Liguori, Alessia (Author), Sangesland, Maya (Author), Lingwood, Daniel (Author), Crispin, Max (Author), Schief, William R. (Author), Irvine, Darrell J (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2020-07-17T20:29:08Z.
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