APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types

APOE4 Causes Widespread Molecular and Cellular Alterations Associated with Alzheimer's Disease Phenotypes in Human iPSC-Derived Brain Cell Types

The apolipoprotein E4 (APOE4) variant is the single greatest genetic risk factor for sporadic Alzheimer's disease (sAD). However, the cell-type-specific functions of APOE4 in relation to AD pathology remain understudied. Here, we utilize CRISPR/Cas9 and induced pluripotent stem cells (iPSCs) to...

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Main Authors: Lin, Yuan-Ta (Author), Seo, Jinsoo (Author), Gao, Fan (Author), Feldman, Heather M. (Author), Wen, Hsin-Lan (Author), Penney, Jay (Author), Cam, Hugh P. (Author), Gjoneska, Elizabeta (Author), Raja, Waseem K (Author), Cheng, Jemmie (Author), Rueda IV, Richard (Author), Kritskiy, Oleg (Author), Abdurrob, Fatema (Author), Peng, Zhuyu (Author), Milo, Blerta (Author), Yu, Chung Jong (Author), Elmsaouri, Sara (Author), Dey, Dilip Chandra (Author), Ko, Tak (Author), Yankner, Bruce A. (Author), Tsai, Li-Huei (Author)
Other Authors: Picower Institute for Learning and Memory (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-07-24T14:26:24Z.
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