Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

Efficient generation of Knock-in/Knock-out marmoset embryo via CRISPR/Cas9 gene editing

Genetically modified nonhuman primates (NHP) are useful models for biomedical research. Gene editing technologies have enabled production of target-gene knock-out (KO) NHP models. Target-gene-KO/knock-in (KI) efficiency of CRISPR/Cas9 has not been extensively investigated in marmosets. In this study...

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Main Authors: Kumita, Wakako (Author), Sato, Kenya (Author), Suzuki, Yasuhiro (Author), Kurotaki, Yoko (Author), Harada, Takeshi (Author), Zhou, Yang (Author), Kishi, Noriyuki (Author), Sato, Kengo (Author), Aiba, Atsu (Author), Sakakibara, Yasubumi (Author), Feng, Guoping (Author), Okano, Hideyuki (Author), Sasaki, Erika (Author)
Other Authors: McGovern Institute for Brain Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-07-27T21:24:50Z.
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