REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease

REST and Neural Gene Network Dysregulation in iPSC Models of Alzheimer's Disease

The molecular basis of the earliest neuronal changes that lead to Alzheimer's disease (AD) is unclear. Here, we analyze neural cells derived from sporadic AD (SAD), APOE4 gene-edited and control induced pluripotent stem cells (iPSCs). We observe major differences in iPSC-derived neural progenit...

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Main Authors: Meyer, Katharina (Author), Feldman, Heather M. (Author), Lu, Tao (Author), Drake, Derek (Author), Lim, Elaine T. (Author), Ling, King-Hwa (Author), Bishop, Nicholas A. (Author), Pan, Ying (Author), Seo, Jinsoo (Author), Lin, Yuan-Ta (Author), Su, Susan C. (Susan Chih-Chieh) (Author), Church, George M. (Author), Tsai, Li-Huei (Author), Yankner, Bruce A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Picower Institute for Learning and Memory (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-07-27T21:42:04Z.
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