Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

Gut-Liver Physiomimetics Reveal Paradoxical Modulation of IBD-Related Inflammation by Short-Chain Fatty Acids

Although the association between the microbiome and IBD and liver diseases is known, the cause and effect remain elusive. By connecting human microphysiological systems of the gut, liver, and circulating Treg and Th17 cells, we created a multi-organ model of ulcerative colitis (UC) ex vivo. The appr...

Full description

Bibliographic Details
Main Authors: Trapecar, Martin (Author), Communal, Catherine (Author), Velazquez, Jason G (Author), Maass, Christian Alexander (Author), Huang, Yu-Ja (Author), Schneider, Kirsten (Author), Wright, Charles (Author), Butty, Vincent L G (Author), Eng, George M. (Author), Yilmaz, Omer (Author), Trumper, David L (Author), Griffith, Linda G (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Massachusetts Institute of Technology. Research Laboratory of Electronics (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-07-31T20:50:22Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items