High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

High-Resolution Structure of Cas13b and Biochemical Characterization of RNA Targeting and Cleavage

Type VI CRISPR-Cas systems contain programmable single-effector RNA-guided RNases, including Cas13b, one of the four known family members. Cas13b, which has been used for both RNA editing and nucleic acid detection, is unique among type VI CRISPR effectors in its linear domain architecture and CRISP...

Full description

Bibliographic Details
Main Authors: Slaymaker, Ian (Author), Mesa, Pablo (Author), Kellner, Max J. (Author), Kannan, Soumya (Author), Brignole, Edward J (Author), Koob, Jeremy (Author), Feliciano, Patricia Rosa (Author), Stella, Stefano (Author), Abudayyeh, Omar O. (Author), Gootenberg, Jonathan S (Author), Strecker, Jonathan (Author), Montoya, Guillermo (Author), Zhang, Feng (Author)
Other Authors: McGovern Institute for Brain Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Harvard University- (Contributor), Broad Institute of MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-08-06T17:56:31Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items