The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

The NORAD lncRNA assembles a topoisomerase complex critical for genome stability

The human genome contains thousands of long non-coding RNAs1, but specific biological functions and biochemical mechanisms have been discovered for only about a dozen2-7. A specific long non-coding RNA-non-coding RNA activated by DNA damage (NORAD)-has recently been shown to be required for maintain...

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Main Authors: Munschauer, Mathias (Author), Nguyen, Celina T. (Author), Sirokman, Klara (Author), Hartigan, Christina R. (Author), Hogstrom, Larson (Author), Engreitz, Jesse Michael (Author), Ulirsch, Jacob C. (Author), Fulco, Charles P. (Author), Subramanian, Vidya (Author), Chen, Jenny (Author), Schenone, Monica (Author), Guttman, Mitchell (Author), Carr, Steven A (Author), Lander, Eric Steven (Author)
Other Authors: Harvard University- (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor), Broad Institute of MIT and Harvard (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2020-08-14T16:31:29Z.
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