Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

Transcriptional Atlas of Intestinal Immune Cells Reveals that Neuropeptide α-CGRP Modulates Group 2 Innate Lymphoid Cell Responses

Signaling abnormalities in immune responses in the small intestine can trigger chronic type 2 inflammation involving interaction of multiple immune cell types. To systematically characterize this response, we analyzed 58,067 immune cells from the mouse small intestine by single-cell RNA sequencing (...

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Main Authors: Xu, Heping (Author), Ding, Jiarui (Author), Porter, Caroline (Author), Wallrapp, Antonia (Author), Tabaka, Marcin (Author), Ma, Sai (Author), Fu, Shujie (Author), Guo, Xuanxuan (Author), Riesenfeld, Samantha J. (Author), Su, Chienwen (Author), Dionne, Danielle (Author), Nguyen, Lan T. (Author), Lefkovith, Ariel (Author), Ashenberg, Orr (Author), Burkett, Patrick R. (Author), Shi, Hai Ning (Author), Rozenblatt-Rosen, Orit (Author), Graham, Daniel B. (Author), Kuchroo, Vijay K. (Author), Regev, Aviv (Author), Xavier, Ramnik J. (Author)
Other Authors: Broad Institute of MIT and Harvard (Contributor), Massachusetts Institute of Technology. Department of Biology (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-08-24T15:19:40Z.
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