Computationally Guided Intracerebral Drug Delivery via Chronically Implanted Microdevices

Computationally Guided Intracerebral Drug Delivery via Chronically Implanted Microdevices

Treatments for neurologic diseases are often limited in efficacy due to poor spatial and temporal control over their delivery. Intracerebral delivery partially overcomes this by directly infusing therapeutics to the brain. Brain structures, however, are nonuniform and irregularly shaped, precluding...

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Main Authors: Ramadi, Khalil (Author), Bashyam, Ashvin (Author), Frangieh, Chris J. (Author), Rousseau, Erin Byrne (Author), Cotler, Max Joseph (Author), Langer, Robert S (Author), Graybiel, Ann M (Author), Cima, Michael J. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science (Contributor), McGovern Institute for Brain Research at MIT (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-09-09T13:37:35Z.
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