An on-chip model of protein paracellular and transcellular permeability in the microcirculation

Recent therapeutic success of large-molecule biologics has led to intense interest in assays to measure with precision their transport across the vascular endothelium and into the target tissue. Most current in vitro endothelial models show unrealistically large permeability coefficients due to a no...

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Bibliographic Details
Main Authors: Offeddu, Giovanni (Author), Haase, Kristina Michelle (Author), Gillrie, Mark Robert (Author), Li, Ran (Author), Morozova, Olga (Author), Hickman, Dean (Author), Knutson, Charles G. (Author), Kamm, Roger Dale (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Mechanical Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-10-29T22:37:39Z.
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