Synthesis of proteins by automated flow chemistry

Synthesis of proteins by automated flow chemistry

Ribosomes can produce proteins in minutes and are largely constrained to proteinogenic amino acids. Here, we report highly efficient chemistry matched with an automated fast-flow instrument for the direct manufacturing of peptide chains up to 164 amino acids long over 327 consecutive reactions. The...

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Main Authors: Hartrampf, Nina (Author), Saebi, Azin (Author), Poskus, M. (Author), Gates, Zachary P (Author), Callahan, A. J. (Author), Cowfer, A. E. (Author), Hanna, S. (Author), Antilla, S. (Author), Schissel, Carly K. (Author), Quartararo, Anthony James (Author), Ye, Xiyun (Author), Mijalis, Alexander James (Author), Simon, M. D. (Author), Loas, Andrei Ioan (Author), Liu, S. (Author), Jessen, C. (Author), Nielsen, T. E. (Author), Pentelute, Bradley L. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Association for the Advancement of Science (AAAS), 2020-12-09T21:01:13Z.
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