Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers

Improving Drug Discovery by Nucleic Acid Delivery in Engineered Human Microlivers

The liver plays a central role in metabolism; however, xenobiotic metabolism variations between human hepatocytes and those in model organisms create challenges in establishing functional test beds to detect the potential drug toxicity and efficacy of candidate small molecules. In the emerging areas...

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Bibliographic Details
Main Authors: Mancio Silva, Liliana (Author), Fleming, Heather (Author), Miller, Alex B (Author), Milstein, Stuart (Author), Liebow, Abigail (Author), Haslett, Patrick (Author), Sepp-Lorenzino, Laura (Author), Bhatia, Sangeeta N (Author)
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2020-12-18T19:59:53Z.
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