Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles

Self-replicating RNAs derived from alphaviruses have high potential for vaccine applications. Utilizing lipid nanoparticle-formulated RNA replicons as a vaccine platform to deliver self-assembling protein immunogens, Melo et al. demonstrate robust anti-HIV Env antibody production and significantly i...

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Bibliographic Details
Main Authors: Melo, Mariane Bandeira (Author), Porter, Ely (Author), Zhang, Yuan (Author), Silva, Murillo (Author), Li, Na (Author), Dobosh, Brian S (Author), Liguori, Alessia (Author), Skog, Pat (Author), Landais, Elise (Author), Menis, Sergey (Author), Sok, Devin (Author), Nemazee, David (Author), Schief, William R. (Author), Weiss, Ron (Author), Irvine, Darrell J (Author)
Other Authors: Massachusetts Institute of Technology. Synthetic Biology Center (Contributor), Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Massachusetts Institute of Technology. Department of Materials Science and Engineering (Contributor), Koch Institute for Integrative Cancer Research at MIT (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2021-01-07T21:42:16Z.
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