Immunogenicity of RNA Replicons Encoding HIV Env Immunogens Designed for Self-Assembly into Nanoparticles
Self-replicating RNAs derived from alphaviruses have high potential for vaccine applications. Utilizing lipid nanoparticle-formulated RNA replicons as a vaccine platform to deliver self-assembling protein immunogens, Melo et al. demonstrate robust anti-HIV Env antibody production and significantly i...
Main Authors: | , , , , , , , , , , , , , , |
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Other Authors: | , , , |
Format: | Article |
Language: | English |
Published: |
Elsevier BV,
2021-01-07T21:42:16Z.
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Subjects: | |
Online Access: | Get fulltext |