Joint profiling of DNA methylation and chromatin architecture in single cells

Joint profiling of DNA methylation and chromatin architecture in single cells

We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both t...

Full description

Bibliographic Details
Main Authors: Li, Guoqiang (Author), Liu, Yaping (Author), Zhang, Yanxiao (Author), Kubo, Naoki (Author), Yu, Miao (Author), Fang, Rongxin (Author), Kellis, Manolis (Author), Ren, Bing (Author)
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor)
Format: Article
Language:English
Published: Springer Science and Business Media LLC, 2021-01-12T22:56:58Z.
Subjects:
Article
Online Access:Get fulltext

Internet

Get fulltext

Similar Items