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129395 |
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|a Li, Guoqiang
|e author
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|a Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
|e contributor
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|a Liu, Yaping
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|a Zhang, Yanxiao
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|a Kubo, Naoki
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|a Yu, Miao
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|a Fang, Rongxin
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|a Kellis, Manolis
|e author
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|a Ren, Bing
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|a Joint profiling of DNA methylation and chromatin architecture in single cells
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|b Springer Science and Business Media LLC,
|c 2021-01-12T22:56:58Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/129395
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|a We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both the chromatin architecture and DNA methylome in a mixed population. It enables simultaneous characterization of cell-type-specific chromatin organization and epigenome in complex tissues.
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|a Article
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|t Nature Methods
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