Joint profiling of DNA methylation and chromatin architecture in single cells
We report a molecular assay, Methyl-HiC, that can simultaneously capture the chromosome conformation and DNA methylome in a cell. Methyl-HiC reveals coordinated DNA methylation status between distal genomic segments that are in spatial proximity in the nucleus, and delineates heterogeneity of both t...
Main Authors: | Li, Guoqiang (Author), Liu, Yaping (Author), Zhang, Yanxiao (Author), Kubo, Naoki (Author), Yu, Miao (Author), Fang, Rongxin (Author), Kellis, Manolis (Author), Ren, Bing (Author) |
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Other Authors: | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory (Contributor) |
Format: | Article |
Language: | English |
Published: |
Springer Science and Business Media LLC,
2021-01-12T22:56:58Z.
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Subjects: | |
Online Access: | Get fulltext |
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