Synthesis of Pyrroles through the CuH-Catalyzed Coupling of Enynes and Nitriles

Herein, we describe an efficient method to prepare polysubstituted pyrroles via a copper hydride (CuH)-catalyzed enyne-nitrile coupling reaction. This protocol accommodates both aromatic and aliphatic substituents and a broad range of functional groups, providing a variety of N-H pyrroles in good yi...

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Bibliographic Details
Main Authors: Zhou, Yujing (Author), Zhou, Lin (Author), Jesikiewicz, Luke T (Author), Liu, Peng (Author), Buchwald, Stephen Leffler (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: American Chemical Society (ACS), 2021-01-14T20:04:54Z.
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