Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors

Targeted polypharmacology provides an efficient method of treating diseases such as cancer with complex, multigenic causes provided that compounds with advantageous activity profiles can be discovered. Novel covalent TAK1 inhibitors were validated in cellular contexts for their ability to inhibit th...

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Bibliographic Details
Main Authors: Tan, Li (Author), Gurbani, Deepak (Author), Weisberg, Ellen L. (Author), Jones II, Douglas S. (Author), Rao, Suman (Author), Singer, William D. (Author), Bernard, Faviola M. (Author), Mowafy, Samar (Author), Jenney, Annie (Author), Du, Guangyan (Author), Nonami, Atsushi (Author), Griffin, James D. (Author), Lauffenburger, Douglas A (Author), Westover, Kenneth D. (Author), Sorger, Peter K. (Author), Gray, Nathanael S. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2021-01-20T19:18:47Z.
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