Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

Mediator Condensates Localize Signaling Factors to Key Cell Identity Genes

The gene expression programs that define the identity of each cell are controlled by master transcription factors (TFs) that bind cell-type-specific enhancers, as well as signaling factors, which bring extracellular stimuli to these enhancers. Recent studies have revealed that master TFs form phase-...

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Main Authors: Zamudio Montes de Oca, Alicia (Author), Dall'Agnese, Alessandra (Author), Henninger, Jonathan E. (Author), Manteiga, John Colonnese (Author), Afeyan, Lena K. (Author), Hannett, Nancy M. (Author), Coffey, Eliot Leo (Author), Li, Charles Han (Author), Oksuz, Ozgur (Author), Sabari, Benjamin R. (Author), Boija, Ann (Author), Klein, Isaac A. (Author), Hawken, Susana W (Author), Spille, Jan Hendrik (Author), Cisse, Ibrahim I (Author), Abraham, Brian Joseph (Author), Lee, Tong Ihn (Author), Taatjes, Dylan J. (Author), Schuijers, Jurian (Author), Young, Richard A. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biology (Contributor), Massachusetts Institute of Technology. Department of Physics (Contributor), Whitehead Institute for Biomedical Research (Contributor), Massachusetts Institute of Technology. Computational and Systems Biology Program (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2021-01-21T16:43:27Z.
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