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|a dc
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|a Mercado, Noe B.
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|a Ragon Institute of MGH, MIT and Harvard
|e contributor
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|a Massachusetts Institute of Technology. Department of Biological Engineering
|e contributor
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|a Zahn, Roland
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|a Wegmann, Frank
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|a Loos, Carolin
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|a Chandrashekar, Abishek
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|a Yu, Jingyou
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|a Liu, Jinyan
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|a Peter, Lauren
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|a McMahan, Katherine
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|a Tostanoski, Lisa H.
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|a He, Xuan
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|a Martinez, David R.
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|a Rutten, Lucy
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|a Bos, Rinke
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|a van Manen, Danielle
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|a Vellinga, Jort
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|a Custers, Jerome
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|a Langedijk, Johannes P.
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|a Kwaks, Ted
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|a Bakkers, Mark J. G.
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|a Zuijdgeest, David
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|a Rosendahl Huber, Sietske K.
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|a Atyeo, Caroline
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|a Fischinger, Stephanie
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|a Burke, John
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|a Feldman, Jared
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|a Hauser, Blake Marie
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|a Caradonna, Timothy M.
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|a Bondzie, Esther A.
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|a Dagotto, Gabriel
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|a Gebre, Makda S.
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|a Hoffman, Emily
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|a Jacob-Dolan, Catherine
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|a Kirilova, Marinela
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|a Li, Zhenfeng
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|a Lin, Zijin
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|a Mahrokhian, Shant H.
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|a Maxfield, Lori F.
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|a Nampanya, Felix
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|a Nityanandam, Ramya
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|a Nkolola, Joseph P.
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|a Patel, Shivani
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|a Ventura, John D.
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|a Verrington, Kaylee
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|a Wan, Huahua
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|a Pessaint, Laurent
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|a Van Ry, Alex
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|a Blade, Kelvin
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|a Strasbaugh, Amanda
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|a Cabus, Mehtap
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|a Brown, Renita
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|a Cook, Anthony
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|a Zouantchangadou, Serge
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|a Teow, Elyse
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|a Andersen, Hanne
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|a Lewis, Mark G.
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|a Cai, Yongfei
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|a Chen, Bing
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|a Schmidt, Aaron G.
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|a Reeves, R. Keith
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|a Baric, Ralph S.
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|a Lauffenburger, Douglas A.
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|a Alter, Galit
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|a Stoffels, Paul
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|a Mammen, Mathai
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|a Van Hoof, Johan
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|a Schuitemaker, Hanneke
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|a Barouch, Dan
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|a Single-shot Ad26 vaccine protects against SARS-CoV-2 in rhesus macaques
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|b Springer Science and Business Media LLC,
|c 2021-02-04T17:02:21Z.
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|z Get fulltext
|u https://hdl.handle.net/1721.1/129676
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|a A safe and effective vaccine for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) may be required to end the coronavirus disease 2019 (COVID-19) pandemic1-8. For global deployment and pandemic control, a vaccine that requires only a single immunization would be optimal. Here we show the immunogenicity and protective efficacy of a single dose of adenovirus serotype 26 (Ad26) vector-based vaccines expressing the SARS-CoV-2 spike (S) protein in non-human primates. Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vectors that encoded S variants or sham control, and then challenged with SARS-CoV-2 by the intranasal and intratracheal routes9,10. The optimal Ad26 vaccine induced robust neutralizing antibody responses and provided complete or near-complete protection in bronchoalveolar lavage and nasal swabs after SARS-CoV-2 challenge. Titres of vaccine-elicited neutralizing antibodies correlated with protective efficacy, suggesting an immune correlate of protection. These data demonstrate robust single-shot vaccine protection against SARS-CoV-2 in non-human primates. The optimal Ad26 vector-based vaccine for SARS-CoV-2, termed Ad26.COV2.S, is currently being evaluated in clinical trials.
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|a en
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|a Article
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|t Nature
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