Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

Risk of rapid evolutionary escape from biomedical interventions targeting SARS-CoV-2 spike protein

The spike protein receptor-binding domain (RBD) of SARS-CoV-2 is the molecular target for many vaccines and antibody-based prophylactics aimed at bringing COVID-19 under control. Such a narrow molecular focus raises the specter of viral immune evasion as a potential failure mode for these biomedical...

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Bibliographic Details
Main Authors: Van Egeren, Debra (Author), Novokhodko, Alexander (Author), Stoddard, Madison (Author), Tran, Uyen (Author), Zetter, Bruce (Author), Rogers, Michael (Author), Pentelute, Bradley L. (Author), Carlson, Jonathan M. (Author), Hixon, Mark (Author), Joseph-McCarthy, Diane (Author), Chakravarty, Arijit (Author)
Other Authors: Massachusetts Institute of Technology. Department of Chemistry (Contributor)
Format: Article
Language:English
Published: Public Library of Science (PLoS), 2021-05-03T20:38:24Z.
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