Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Longitudinal proteomic analysis of severe COVID-19 reveals survival-associated signatures, tissue-specific cell death, and cell-cell interactions

Mechanisms underlying severe coronavirus disease 2019 (COVID-19) disease remain poorly understood. We analyze several thousand plasma proteins longitudinally in 306 COVID-19 patients and 78 symptomatic controls, uncovering immune and non-immune proteins linked to COVID-19. Deconvolution of our plasm...

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Main Authors: Filbin, Michael R. (Author), Mehta, Arnav (Author), Schneider, Alexis M. (Author), Kays, Kyle R. (Author), Guess, Jamey R. (Author), Gentili, Matteo (Author), Fenyves, Bánk G. (Author), Charland, Nicole C. (Author), Gonye, Anna L.K (Author), Gushterova, Irena (Author), Khanna, Hargun K. (Author), LaSalle, Thomas J. (Author), Lavin-Parsons, Kendall M. (Author), Lilley, Brendan M. (Author), Lodenstein, Carl L. (Author), Manakongtreecheep, Kasidet (Author), Margolin, Justin D. (Author), McKaig, Brenna N. (Author), Rojas-Lopez, Maricarmen (Author), Russo, Brian C. (Author), Sharma, Nihaarika (Author), Tantivit, Jessica (Author), Thomas, Molly F. (Author), Gerszten, Robert E. (Author), Heimberg, Graham S. (Author), Hoover, Paul J. (Author), Lieb, David J. (Author), Lin, Brian (Author), Ngo, Debby (Author), Pelka, Karin (Author), Reyes, Miguel (Author), Smillie, Chris S (Author), Waghray, Avinash (Author), Wood, Thomas E. (Author), Zajac, Amanda S. (Author), Jennings, Lori L. (Author), Grundberg, Ida (Author), Bhattacharyya, Roby P. (Author), Parry, Blair Alden (Author), Villani, Alexandra-Chloé (Author), Sade-Feldman, Moshe (Author), Hacohen, Nir (Author), Goldberg, Marcia B. (Author)
Other Authors: Massachusetts Institute of Technology. Department of Biological Engineering (Contributor), Broad Institute of MIT and Harvard (Contributor)
Format: Article
Language:English
Published: Elsevier BV, 2021-07-21T21:51:47Z.
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